Studying brain illness through neuroscience, immunology, and genomics.

We apply diverse scientific disciplines and technologies to investigate the fundamentals of brain-related disorders (such as schizophrenia and Alzheimer’s disease), and how we can treat or reverse their effects.

had-1r-gm
had-1r-gm
had-1r-gm
G10_scr_mAs_PKACA_488_Homer1_594_Basson_647_MAP2_420_63x
slider-had-1r-gm

Complement RNA across the Adult Mouse Brain
Spatial distribution of RNA molecules for C1qa (green), Nptx1 (light blue), Nptx2 (orange), C4b (red) and Cd55 (dark blue) labeled by MERFISH.

READ MORE >

slider-had-1r-gm

Genetic Risk Factor for Schizophrenia
In health, Complement C4 (green) is restricted to blood vessels, but during neurodegeneration, astrocytes (red) become reactive and secrete C4 into the brain tissue.

READ MORE >

slider-1-GPe-Neurons

Nontraditional Circuitry
Cortically-projection neurons (red) send their axons into the insular cortex of the mouse globus pallidus externus (GPe, green).

READ MORE >

mAs-PKACA

Visualizing Neurons in Culture
Homer1 (orange) and Bassoon (red) localize to the synapses of healthy neurons (blue), while Protein Kinase A (green) is found all over.

READ MORE >

previous arrowprevious arrow
next arrownext arrow
had-1r-gm
had-1r-gm
had-1r-gm

Complement RNA across the Adult Mouse Brain
Spatial distribution of RNA molecules for C1qa (green), Nptx1 (light blue), Nptx2 (orange), C4b (red) and Cd55 (dark blue) labeled by MERFISH.
READ MORE >

Genetic Risk Factor for Schizophrenia
In health, Complement C4 (green) is restricted to blood vessels, but during neurodegeneration, astrocytes (red) become reactive and secrete C4 into the brain tissue.
READ MORE >

Nontraditional Circuitry
Cortically-projection neurons (red) send their axons into the insular cortex of the mouse globus pallidus externus (GPe, green).
READ MORE >

Visualizing Neurons in Culture
Homer1 (orange) and Bassoon (red) localize to the synapses of healthy neurons (blue), while Protein Kinase A (green) is found all over.
READ MORE >

Featured Center News
March 26, 2021

Thank you for attending the Virtual 2021 Conte Center Symposium!

We greatly appreciate all the speakers and attendees who were able to make it, despite the switch to a virtual format. We look forward to seeing you in person for the 2024 Symposium.
May 2024

Center work presented at the Lake Conference in Switzerland

Drs. Kevin Mastro and Matthew Johnson gave exciting updates on our current work in brain development and psychiatric illness. Hope you had a chance to see their amazing talks.