Conte Center for Neuroimmune Studies |

Studying brain illness through neuroscience, immunology, and genomics.

We apply diverse scientific disciplines and technologies to investigate the fundamentals of brain-related disorders (such as schizophrenia and Alzheimer’s disease), and how we can treat or reverse their effects.

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Complement RNA across the Adult Mouse Brain
Spatial distribution of RNA molecules for C1qa (green), Nptx1 (light blue), Nptx2 (orange), C4b (red) and Cd55 (dark blue) labeled by MERFISH.

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Genetic Risk Factor for Schizophrenia
In health, Complement C4 (green) is restricted to blood vessels, but during neurodegeneration, astrocytes (red) become reactive and secrete C4 into the brain tissue.

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Nontraditional Circuitry
Cortically-projection neurons (red) send their axons into the insular cortex of the mouse globus pallidus externus (GPe, green).

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Visualizing Neurons in Culture
Homer1 (orange) and Bassoon (red) localize to the synapses of healthy neurons (blue), while Protein Kinase A (green) is found all over.

Complement RNA across the Adult Mouse Brain
Spatial distribution of RNA molecules for C1qa (green), Nptx1 (light blue), Nptx2 (orange), C4b (red) and Cd55 (dark blue) labeled by MERFISH.
READ MORE >

Genetic Risk Factor for Schizophrenia
In health, Complement C4 (green) is restricted to blood vessels, but during neurodegeneration, astrocytes (red) become reactive and secrete C4 into the brain tissue.
READ MORE >

Nontraditional Circuitry
Cortically-projection neurons (red) send their axons into the insular cortex of the mouse globus pallidus externus (GPe, green).
READ MORE >

Visualizing Neurons in Culture
Homer1 (orange) and Bassoon (red) localize to the synapses of healthy neurons (blue), while Protein Kinase A (green) is found all over.
READ MORE >

Featured Center News

July 23, 2024

Registration for the 2024 Conte Center Symposium is now open

The Conte Center cordially invites you to attend our 2024 symposium on Neuroimmune symposium on Neuroimmune Mechanisms of Brain Development and Psychiatric Illness, located at the Broad Institute of MIT and Harvard on Tuesday October 15, 2024. Please find the full details on this post.

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May 2024

Center work presented at the Lake Conference in Switzerland

Drs. Kevin Mastro and Matthew Johnson gave exciting updates on our current work in brain development and psychiatric illness. Hope you had a chance to see their amazing talks.

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